Ginsenoside Rb1 Blocks Ritonavir-Induced Oxidative Stress and eNOS Downregulation through Activation of Estrogen Receptor-Beta and Upregulation of SOD in Human Endothelial Cells

Ginsenoside Rb1 Blocks Ritonavir-Induced Oxidative Stress and eNOS Downregulation through Activation of Estrogen Receptor-Beta and Upregulation of SOD in Human Endothelial Cells

We have previously shown that ritonavir (RTV), a highly active anti-retroviral therapy (HAART) drug, can cause endothelial dysfunction through oxidative stress. Several antioxidants including ginsenoside Rb1, a compound with antioxidant effect, can effectively block this side effect of RTV in endoth...

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Bibliographic Details
Main Authors: Jian-Ming Lü, Jun Jiang, Md Saha Jamaluddin, Zhengdong Liang, Qizhi Yao, Changyi Chen
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:International Journal of Molecular Sciences
Subjects:
ginsenoside Rb1
ritonavir
oxidative stress
endothelial nitric oxidase synthase
estrogen receptor
superoxide dismutase
endothelial dysfunction
Online Access:http://www.mdpi.com/1422-0067/20/2/294

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http://www.mdpi.com/1422-0067/20/2/294

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