Identification of novel sarcoma risk genes using a two-stage genome wide DNA sequencing strategy in cancer cluster families and population case and control cohorts

Identification of novel sarcoma risk genes using a two-stage genome wide DNA sequencing strategy in cancer cluster families and population case and control cohorts

Abstract Background Although familial clustering of cancers is relatively common, only a small proportion of familial cancer risk can be explained by known cancer predisposition genes. Methods In this study we employed a two-stage approach to identify candidate sarcoma risk genes. First, we conducte...

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Bibliographic Details
Main Authors: Rachel M. Jones, Phillip E. Melton, Mark Pinese, Alexander J. Rea, Evan Ingley, Mandy L. Ballinger, International Sarcoma Kindred Study, David J. Wood, David M. Thomas, Eric K. Moses
Format: Article
Language:English
Published: BMC 2019-05-01
Series:BMC Medical Genetics
Subjects:
Sarcoma
Whole exome sequencing
Cancer cluster families
Genetic risk variants
Whole genome sequencing
Online Access:http://link.springer.com/article/10.1186/s12881-019-0808-9

Internet

http://link.springer.com/article/10.1186/s12881-019-0808-9

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