Zinc regulates the acute phase response and serum amyloid A production in response to sepsis through JAK-STAT3 signaling.

Zinc regulates the acute phase response and serum amyloid A production in response to sepsis through JAK-STAT3 signaling.

Sepsis rapidly activates the host inflammatory response and acute phase response. Severe sepsis, complicated by multiple organ failure, is associated with overwhelming inflammation and high mortality. We previously observed that zinc (Zn) deficiency significantly increases mortality in a mouse model...

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Bibliographic Details
Main Authors: Ming-Jie Liu, Shengying Bao, Jessica R Napolitano, Dara L Burris, Lianbo Yu, Susheela Tridandapani, Daren L Knoell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3986341?pdf=render

Internet

http://europepmc.org/articles/PMC3986341?pdf=render

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