Evaluation of cytotoxicity and mutagenicity of the benzodiazepine flunitrazepam in vitro and in vivo

Evaluation of cytotoxicity and mutagenicity of the benzodiazepine flunitrazepam in vitro and in vivo

Flunitrazepam (FNZ) is a sedative benzodiazepine prescribed for the short-term treatment of insomnia. However, there are concerns regarding possible carcinogenic or genotoxic effects of this medicine. Thus, the aim of this study was to evaluate the cytotoxic, clastogenic and aneugenic effects of FNZ...

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Bibliographic Details
Main Authors: Igor Vivian de Almeida, Giovana Domingues, Lilian Capelari Soares, Elisângela Düsman, Veronica Elisa Pimenta Vicentini
Format: Article
Language:English
Published: Universidade de São Paulo 2014-04-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
Flunitrazepam/efeitos citotóxicos
Flunitrazepam/efeitos clastogênicos
Flunitrazepam/efeitos aneugênicos
Sedativo benzodiazepínico/efeitos adversos/estudo in vitro e in vivo
Anormalidades cromossômicas/efeitos de medicamentos
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000200251&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000200251&lng=en&tlng=en

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