Interleukin-10 Promotes Porcine Circovirus Type 2 Persistent Infection in Mice and Aggravates the Tissue Lesions by Suppression of T Cell Infiltration

Interleukin-10 Promotes Porcine Circovirus Type 2 Persistent Infection in Mice and Aggravates the Tissue Lesions by Suppression of T Cell Infiltration

Interleukin (IL)-10, as a key anti-inflammatory cytokine, increases during porcine circovirus type 2 (PCV2) infection, but the role of IL-10 in the process remains to be defined. In the present study, using an IL-10 deficient mice model, we found that IL-10 deficiency prevented the reduction of sple...

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Bibliographic Details
Main Authors: Qian Du, Huan Zhang, Mingrui He, Xuan Zhao, Jia He, Beibei Cui, Xuefeng Yang, Dewen Tong, Yong Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Microbiology
Subjects:
porcine circovirus type 2
interleukin-10
lymphocytes
T cells
chemokines
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.02050/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2019.02050/full

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