Clinical Relevant Polymorphisms Affecting Clopidogrel Pharmacokinetics and Pharmacodynamics: Insights from the Puerto Rico Newborn Screening Program

Clinical Relevant Polymorphisms Affecting Clopidogrel Pharmacokinetics and Pharmacodynamics: Insights from the Puerto Rico Newborn Screening Program

Background: Variations in several clopidogrel-pharmacogenes have been linked to clopidogrel response variability and clinical outcomes. We aimed to determine the frequency distribution of major polymorphisms on CYP2C19, PON1, ABCB1 and P2RY12 pharmacogenes in Puerto Ricans. Methods: This was a cross...

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Bibliographic Details
Main Authors: Dagmar F. Hernandez-Suarez, Jonnalie C. Tomassini-Fernandini, Angelica Cuevas, Anyelis N. Rosario-Berrios, Héctor J. Nuñez-Medina, Dariana Padilla-Arroyo, Nannette Rivera, Jennifer Liriano, Rocio K. Vega-Roman, Jessicca Y. Renta, Kyle Melin, Jorge Duconge
Format: Article
Language:English
Published: MDPI AG 2018-05-01
Series:International Journal of Environmental Research and Public Health
Subjects:
clopidogrel
pharmacogenetics
Puerto Ricans
genotypes
allele frequency
Online Access:http://www.mdpi.com/1660-4601/15/6/1115

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http://www.mdpi.com/1660-4601/15/6/1115

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