DNA methylation and repressive histones in the promoters of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, PD-L1, and galectin-9 genes in human colorectal cancer

DNA methylation and repressive histones in the promoters of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, PD-L1, and galectin-9 genes in human colorectal cancer

Abstract Background Colorectal cancer (CRC) is the third most commonly diagnosed human malignancy worldwide. Upregulation of inhibitory immune checkpoints by tumor-infiltrating immune cells (TIICs) or their ligands by tumor cells leads to tumor evasion from host immunosurveillance. Changes in DNA me...

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Bibliographic Details
Main Authors: Varun Sasidharan Nair, Salman M. Toor, Rowaida Z. Taha, Hibah Shaath, Eyad Elkord
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Clinical Epigenetics
Subjects:
Colorectal cancer
Immune checkpoints
PD-L1
Galectin-9
DNA methylation
Histone trimethylation
Online Access:http://link.springer.com/article/10.1186/s13148-018-0539-3

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http://link.springer.com/article/10.1186/s13148-018-0539-3

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