Fibronectin Overexpression Modulates Formation of Macrophage Foam Cells by Activating SREBP2 Involved in Endoplasmic Reticulum Stress

Fibronectin Overexpression Modulates Formation of Macrophage Foam Cells by Activating SREBP2 Involved in Endoplasmic Reticulum Stress

Aims: To explore the explicit role of fibronectin (FN) isforms in atherosclerotic lesions and the underlying mechanisms. Methods and Results: Inducible stable expression was performed, and similar results were observed between EDA+FN (FN containing EDA domain) and EDA-FN (FN devoid of EDA domain). F...

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Bibliographic Details
Main Authors: Hansong Du, Yu Wang, Zhengfeng Zhang, Jing Yang, Jie Zhang, Ying Zhang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-07-01
Series:Cellular Physiology and Biochemistry
Subjects:
Fibronectin
ER stress
SREBP2
Foam cells
Online Access:http://www.karger.com/Article/FullText/430153

Internet

http://www.karger.com/Article/FullText/430153

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