Characterising a human endogenous retrovirus(HERV)-derived tumour-associated antigen: enriched RNA-Seq analysis of HERV-K(HML-2) in mantle cell lymphoma cell lines

Characterising a human endogenous retrovirus(HERV)-derived tumour-associated antigen: enriched RNA-Seq analysis of HERV-K(HML-2) in mantle cell lymphoma cell lines

Abstract Background The cell-surface attachment protein (Env) of the HERV-K(HML-2) lineage of endogenous retroviruses is a potentially attractive tumour-associated antigen for anti-cancer immunotherapy. The human genome contains around 100 integrated copies (called proviruses or loci) of the HERV-K(...

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Bibliographic Details
Main Authors: Witold Tatkiewicz, James Dickie, Franchesca Bedford, Alexander Jones, Mark Atkin, Michele Kiernan, Emmanuel Atangana Maze, Bora Agit, Garry Farnham, Alexander Kanapin, Robert Belshaw
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Mobile DNA
Subjects:
HERV-K(HML-2)
HERV-K
Transposable element
Cancer immunotherapy
Leukemia
NGS
Online Access:https://doi.org/10.1186/s13100-020-0204-1

Internet

https://doi.org/10.1186/s13100-020-0204-1

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