B7-Positive and B7-Negative Acute Myeloid Leukemias Display Distinct T Cell Maturation Profiles, Immune Checkpoint Receptor Expression, and European Leukemia Net Risk Profiles

B7-Positive and B7-Negative Acute Myeloid Leukemias Display Distinct T Cell Maturation Profiles, Immune Checkpoint Receptor Expression, and European Leukemia Net Risk Profiles

Acute myeloid leukemia (AML) is generally considered a poorly immunogenic malignancy, displaying a “non-inflamed” leukemia microenvironment (LME), leading to T cell tolerance. However, the immune landscape of AML is much more heterogeneous. Since B7 expression is regarded as a consequence of an inte...

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Bibliographic Details
Main Authors: Ion Antohe, Angela Dǎscǎlescu, Cǎtǎlin Dǎnǎilǎ, Amalia Titieanu, Mihaela Zlei, Iuliu Ivanov, Adriana Sireteanu, Mariana Pavel, Petru Cianga
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Oncology
Subjects:
acute myeloid leukemia (AML)
immunotherapy
checkpoint ligand
B7 molecules
programmed death 1 (PD-1)
inducible T cell costimulator (ICOS)
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00264/full

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https://www.frontiersin.org/article/10.3389/fonc.2020.00264/full

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