Cilengitide-induced temporal variations in transvascular transfer parameters of tumor vasculature in a rat glioma model: identifying potential MRI biomarkers of acute effects.

Cilengitide-induced temporal variations in transvascular transfer parameters of tumor vasculature in a rat glioma model: identifying potential MRI biomarkers of acute effects.

Increased efficacy of radiotherapy (RT) 4-8 h after Cilengitide treatment has been reported. We hypothesized that the effects of Cilengitide on tumor transvascular transfer parameters might underlie, and thus predict, this potentiation. Athymic rats with orthotopic U251 glioma were studied at ~21 da...

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Bibliographic Details
Main Authors: Tavarekere N Nagaraja, Madhava P Aryal, Stephen L Brown, Hassan Bagher-Ebadian, Tom Mikkelsen, James J Yang, Swayamprava Panda, Kelly A Keenan, Glauber Cabral, James R Ewing
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3871527?pdf=render

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http://europepmc.org/articles/PMC3871527?pdf=render

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