Vaccination with BCGΔBCG1419c protects against pulmonary and extrapulmonary TB and is safer than BCG

Vaccination with BCGΔBCG1419c protects against pulmonary and extrapulmonary TB and is safer than BCG

Abstract A single intradermal vaccination with an antibiotic-less version of BCGΔBCG1419c given to guinea pigs conferred a significant improvement in outcome following a low dose aerosol exposure to M. tuberculosis compared to that provided by a single dose of BCG Pasteur. BCGΔBCG1419c was more atte...

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Bibliographic Details
Main Authors: Michel de Jesús Aceves-Sánchez, Mario Alberto Flores-Valdez, César Pedroza-Roldán, Elizabeth Creissen, Linda Izzo, Fabiola Silva-Angulo, Clinton Dawson, Angelo Izzo, Helle Bielefeldt-Ohmann, Cristian Alfredo Segura-Cerda, Wendy López-Romero, Jorge Bravo-Madrigal, Jorge Alberto Barrios-Payán, Miguel Ángel de la Cruz, Miguel Ares, María Guadalupe Jorge-Espinoza
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-91993-8

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https://doi.org/10.1038/s41598-021-91993-8

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