Immunogenicity and Reactogenicity of Francisella tularensis Strain 15/23-1 recA - the Candidate for a New Live Tularemia Vaccine

Immunogenicity and Reactogenicity of Francisella tularensis Strain 15/23-1 recA - the Candidate for a New Live Tularemia Vaccine

F. tularensis strain 15/23-1 recA is different from the vaccine strain F. tularensis line 15 NIIEG by lacking one from the two copies of iglC gene and recA gene has reduced its reactogenicity for experimental animals (BALB/c mice and guinea pigs): transient weight reduction is less expressed, as wel...

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Bibliographic Details
Main Authors: A. N. Mokrievich, G. M. Titareva, T. I. Kombarova, E. A. Ganina, T. B. Kravchenko, I. V. Bakhteeva, G. M. Vakhrameeva, R. I. Mironova, A. I. Borzilov, O. V. Korobova, V. M. Pavlov, I. A. Dyatlov
Format: Article
Language:Russian
Published: Numikom LLC 2015-12-01
Series:Эпидемиология и вакцинопрофилактика
Subjects:
francisella tularensis
iglc
reca
вакцинный штамм
реактогенность
иммуногенность
vaccine strain
reactogenicity
immunogenicity
Online Access:https://www.epidemvac.ru/jour/article/view/109

Internet

https://www.epidemvac.ru/jour/article/view/109

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