Focal adhesion kinase plays a role in osteoblast mechanotransduction in vitro but does not affect load-induced bone formation in vivo.

Focal adhesion kinase plays a role in osteoblast mechanotransduction in vitro but does not affect load-induced bone formation in vivo.

A healthy skeleton relies on bone's ability to respond to external mechanical forces. The molecular mechanisms by which bone cells sense and convert mechanical stimuli into biochemical signals, a process known as mechanotransduction, are unclear. Focal adhesions play a critical role in cell sur...

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Bibliographic Details
Main Authors: Alesha B Castillo, Jennifer T Blundo, Julia C Chen, Kristen L Lee, Nikitha Reddy Yereddi, Eugene Jang, Shefali Kumar, W Joyce Tang, Sarah Zarrin, Jae-Beom Kim, Christopher R Jacobs
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3448625?pdf=render

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http://europepmc.org/articles/PMC3448625?pdf=render

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