Genome-Wide Analysis of Transposon and Retroviral Insertions Reveals Preferential Integrations in Regions of DNA Flexibility

Genome-Wide Analysis of Transposon and Retroviral Insertions Reveals Preferential Integrations in Regions of DNA Flexibility

DNA transposons and retroviruses are important transgenic tools for genome engineering. An important consideration affecting the choice of transgenic vector is their insertion site preferences. Previous large-scale analyses of Ds transposon integration sites in plants were done on the basis of repor...

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Bibliographic Details
Main Authors: Pavle Vrljicak, Shijie Tao, Gaurav K. Varshney, Helen Ngoc Bao Quach, Adita Joshi, Matthew C. LaFave, Shawn M. Burgess, Karuna Sampath
Format: Article
Language:English
Published: Oxford University Press 2016-04-01
Series:G3: Genes, Genomes, Genetics
Subjects:
transposon
Ac/Ds
genome-wide analysis
integrations
gene targeting
genome engineering
functional genomics
Tol2
retrovirus
MMLV
mouse
ES cells
vertebrate genomes
zebrafish
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.115.026849

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http://g3journal.org/lookup/doi/10.1534/g3.115.026849

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