Design, Synthesis and Biological Evaluation of N-Sulfonyl Homoserine Lactone Derivatives as Inhibitors of Quorum Sensing in Chromobacterium violaceum

Design, Synthesis and Biological Evaluation of N-Sulfonyl Homoserine Lactone Derivatives as Inhibitors of Quorum Sensing in Chromobacterium violaceum

A novel series of N-sulfonyl homoserine lactone derivatives 5a–l has been designed, synthesized and evaluated for quorum sensing inhibitory activities towards violacein production. Of the compounds synthesized, compound 5h was found to possess an excellent level of enantiopurity (99.2% e.e.). The re...

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Bibliographic Details
Main Authors: Junhai Xiao, Yigang Tong, Xiaohong Yang, Fan Feng, Yuhui Hua, Yingying Yu, Mingming Zhao, Hongrui Song
Format: Article
Language:English
Published: MDPI AG 2013-03-01
Series:Molecules
Subjects:
N-sulfonyl homoserine lactone
quorum sensing inhibitor
design
synthesis
Online Access:http://www.mdpi.com/1420-3049/18/3/3266

Internet

http://www.mdpi.com/1420-3049/18/3/3266

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