Divergent roles for KLF4 and TFCP2L1 in naive ground state pluripotency and human primordial germ cell development

Divergent roles for KLF4 and TFCP2L1 in naive ground state pluripotency and human primordial germ cell development

During embryo development, human primordial germ cells (hPGCs) express a naive gene expression program with similarities to pre-implantation naive epiblast (EPI) cells and naive human embryonic stem cells (hESCs). Previous studies have shown that TFAP2C is required for establishing naive gene expres...

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Bibliographic Details
Main Authors: G.V. Hancock, W. Liu, L. Peretz, D. Chen, JJ. Gell, AJ. Collier, JR. Zamudio, K. Plath, AT. Clark
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Stem Cell Research
Subjects:
Primordial Germ Cells
PGCs
hPGCs
Pluripotency
KLF4
TFCP2L1
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506121003408

Internet

http://www.sciencedirect.com/science/article/pii/S1873506121003408

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