Association of polymorphisms of CYP2C9, CYP2C19, and ABCB1, and activity of P-glycoprotein with response to anti-epileptic drugs

Association of polymorphisms of CYP2C9, CYP2C19, and ABCB1, and activity of P-glycoprotein with response to anti-epileptic drugs

Background and Objective: Epilepsy, the most common neurological disorder, has treatment failure rate of 20 to 25%. Inter-individual variability in drug response can be attributed to genetic polymorphism in genes encoding different drug metabolizing enzymes, drug transporters (P-gp), and enzymes inv...

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Bibliographic Details
Main Authors: S R Taur, N B Kulkarni, P P Gandhe, B K Thelma, S H Ravat, N J Gogtay, U M Thatte
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2014-01-01
Series:Journal of Postgraduate Medicine
Subjects:
Drug metabolizing enzymes
efflux transporter
epilepsy
non-responders
pharmacogenomics
Online Access:http://www.jpgmonline.com/article.asp?issn=0022-3859;year=2014;volume=60;issue=3;spage=265;epage=269;aulast=Taur

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http://www.jpgmonline.com/article.asp?issn=0022-3859;year=2014;volume=60;issue=3;spage=265;epage=269;aulast=Taur

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