Lentivirus-mediated downregulation of α-synuclein reduces neuroinflammation and promotes functional recovery in rats with spinal cord injury

Lentivirus-mediated downregulation of α-synuclein reduces neuroinflammation and promotes functional recovery in rats with spinal cord injury

Abstract Background The prognosis of spinal cord injury (SCI) is closely related to secondary injury, which is dominated by neuroinflammation. There is evidence that α-synuclein aggregates after SCI and that inhibition of α-synuclein aggregation can improve the survival of neurons after SCI, but the...

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Bibliographic Details
Main Authors: Hong Zeng, Nan Liu, Yan-yan Yang, Hua-yi Xing, Xiao-xie Liu, Fang Li, Gao-yan La, Meng-jie Huang, Mou-wang Zhou
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Journal of Neuroinflammation
Subjects:
Spinal cord injury
α-Synuclein
Microglia
Astrocyte
Blood-cerebrospinal barrier
Matrix metalloproteinase
Online Access:https://doi.org/10.1186/s12974-019-1658-2

Internet

https://doi.org/10.1186/s12974-019-1658-2

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