Insulin- like Growth Factor-Binding Protein Action in Bone Tissue: A Key Role for Pregnancy- Associated Plasma Protein-A

Insulin- like Growth Factor-Binding Protein Action in Bone Tissue: A Key Role for Pregnancy- Associated Plasma Protein-A

The insulin-like growth factor (IGF) axis is required for the differentiation, development, and maintenance of bone tissue. Accordingly, dysregulation of this axis is associated with various skeletal pathologies including growth abnormalities and compromised bone structure. It is becoming increasing...

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Bibliographic Details
Main Authors: James Beattie, Hasanain Al-Khafaji, Pernille R. Noer, Hanaa Esa Alkharobi, Aishah Alhodhodi, Josephine Meade, Reem El-Gendy, Claus Oxvig
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Endocrinology
Subjects:
insulin-like growth factor-binding protein-4
bone
pregnancy-associated plasma protein-A
proteolysis
insulin-like growth factor-binding protein-5
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2018.00031/full

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https://www.frontiersin.org/article/10.3389/fendo.2018.00031/full

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