Variability in Immunohistochemical Detection of Programmed Death Ligand 1 (PD-L1) in Cancer Tissue Types

Variability in Immunohistochemical Detection of Programmed Death Ligand 1 (PD-L1) in Cancer Tissue Types

In normal cell physiology, programmed death 1 (PD-1) and its ligand, PD-L1, play an immunoregulatory role in T-cell activation, tolerance, and immune-mediated tissue damage. The PD-1/PD-L1 pathway also plays a critical role in immune escape of tumor cells and has been demonstrated to correlate with...

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Bibliographic Details
Main Authors: Giosuè Scognamiglio, Anna De Chiara, Maurizio Di Bonito, Fabiana Tatangelo, Nunzia Simona Losito, Annamaria Anniciello, Rossella De Cecio, Crescenzo D’Alterio, Stefania Scala, Monica Cantile, Gerardo Botti
Format: Article
Language:English
Published: MDPI AG 2016-05-01
Series:International Journal of Molecular Sciences
Subjects:
PD-L1
immunohistochemical staining
tissue type’s variability
Online Access:http://www.mdpi.com/1422-0067/17/5/790

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http://www.mdpi.com/1422-0067/17/5/790

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