J PROTEIN MUTATIONS AND RESULTING PROTEOSTASIS COLLAPSE

J PROTEIN MUTATIONS AND RESULTING PROTEOSTASIS COLLAPSE

Despite a century of intensive investigation the effective treatment of protein aggregation diseases remains elusive. Ordinarily, molecular chaperones ensure that proteins maintain their functional conformation. The appearance of misfolded proteins that aggregate implies the collapse of the cellula...

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Bibliographic Details
Main Authors: Carolina eKoutras, Janice Eva Arlee Braun
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
HSP40 Heat-Shock Proteins
neurodegeneration and neuroprotection
cysteine string protein
DnaJC5
J Protein
DnaJC29
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00191/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00191/full

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