Statin Therapy Negatively Impacts Skeletal Muscle Regeneration and Cutaneous Wound Repair in Type 1 Diabetic Mice

Statin Therapy Negatively Impacts Skeletal Muscle Regeneration and Cutaneous Wound Repair in Type 1 Diabetic Mice

Those with diabetes invariably develop complications including cardiovascular disease (CVD). To reduce their CVD risk, diabetics are generally prescribed cholesterol-lowering 3-hydroxy-methylglutaryl coenzyme A reductase inhibitors (i.e., statins). Statins inhibit cholesterol biosynthesis, but also...

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Bibliographic Details
Main Authors: Irena A. Rebalka, Andrew W. Cao, Matthew J. Raleigh, Brandyn D. Henriksbo, Samantha K. Coleman, Jonathan D. Schertzer, Thomas J. Hawke
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Physiology
Subjects:
Fluvastatin
streptozotocin
diabetes
diabetic wound healing
diabetic myopathy
PAI-1
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.01088/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2017.01088/full

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