Structure and functional analysis of the Legionella pneumophila chitinase ChiA reveals a novel mechanism of metal-dependent mucin degradation.
Chitinases are important enzymes that contribute to the generation of carbon and nitrogen from chitin, a long chain polymer of N-acetylglucosamine that is abundant in insects, fungi, invertebrates and fish. Although mammals do not produce chitin, chitinases have been identified in bacteria that are...
Main Authors: | Saima Rehman, Lubov S Grigoryeva, Katherine H Richardson, Paula Corsini, Richard C White, Rosie Shaw, Theo J Portlock, Benjamin Dorgan, Zeinab S Zanjani, Arianna Fornili, Nicholas P Cianciotto, James A Garnett |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2020-05-01
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Series: | PLoS Pathogens |
Online Access: | https://doi.org/10.1371/journal.ppat.1008342 |
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