Transcriptome Analysis of Immune Receptor Activation and Energy Metabolism Reduction as the Underlying Mechanisms in Interleukin-6-Induced Skeletal Muscle Atrophy

Transcriptome Analysis of Immune Receptor Activation and Energy Metabolism Reduction as the Underlying Mechanisms in Interleukin-6-Induced Skeletal Muscle Atrophy

BackgroundInflammation may trigger skeletal muscle atrophy induced by cancer cachexia. As a pro-inflammatory factor, interleukin-6 may cause skeletal muscle atrophy, but the underlying molecular mechanisms have not been explored.MethodsIn this experimental study, we used adult male ICR mice, weighin...

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Bibliographic Details
Main Authors: Hualin Sun, Junjie Sun, Ming Li, Lei Qian, Lilei Zhang, Ziwei Huang, Yuntian Shen, Betty Yuen-Kwan Law, Liang Liu, Xiaosong Gu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
interleukin-6
muscle atrophy
transcription factor
energy metabolism
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.730070/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.730070/full

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