A period without PER: understanding 24-hour rhythms without classic transcription and translation feedback loops [version 1; peer review: 2 approved]

Since Ronald Konopka and Seymour Benzer’s discovery of the gene Period in the 1970s, the circadian rhythm field has diligently investigated regulatory mechanisms and intracellular transcriptional and translation feedback loops involving Period, and these investigations culminated in a 2017 Nobel Pri...

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Bibliographic Details
Main Authors: Arthur Millius, Koji L. Ode, Hiroki R. Ueda
Format: Article
Language:English
Published: F1000 Research Ltd 2019-04-01
Series:F1000Research
Online Access:https://f1000research.com/articles/8-499/v1