Corticotrigeminal projections from the insular cortex to the trigeminal caudal subnucleus regulate orofacial pain after nerve injury via extracellular signal-regulated kinase activation in insular cortex neurons

Corticotrigeminal projections from the insular cortex to the trigeminal caudal subnucleus regulate orofacial pain after nerve injury via extracellular signal-regulated kinase activation in insular cortex neurons

Cortical neuroplasticity alterations are implicated in the pathophysiology of chronic orofacial pain. However, the relationship between critical cortex excitability and orofacial pain maintenance has not been fully elucidated. We recently demonstrated a top-down corticospinal descending pain modulat...

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Bibliographic Details
Main Authors: Jian eWang, Zhi-Hua eLi, Ban eFeng, Ting eZhang, Han eZhang, Hui eLi, Tao eChen, Jing eCui, Wei-Dong eZang, Yun-Qing eLi
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
neuropathic pain
Extracellular signal-regulated kinase (ERK)
insular cortex (IC)
trigeminal caudal subnucleus (Vc)
IoN-CCI
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00493/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00493/full

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