BRCA2 Regulates Transcription Elongation by RNA Polymerase II to Prevent R-Loop Accumulation

BRCA2 Regulates Transcription Elongation by RNA Polymerase II to Prevent R-Loop Accumulation

The controlled release of RNA polymerase II (RNAPII) from promoter-proximal pausing (PPP) sites is critical for transcription elongation in metazoans. We show that the human tumor suppressor BRCA2 interacts with RNAPII to regulate PPP release, thereby preventing unscheduled RNA-DNA hybrids (R-loops)...

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Bibliographic Details
Main Authors: Mahmud K.K. Shivji, Xavier Renaudin, Çiğdem H. Williams, Ashok R. Venkitaraman
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Cell Reports
Subjects:
BRCA2
R-loops
RNA polymerase II
transcription elongation
PAF1
genomic instability
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471731923X

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http://www.sciencedirect.com/science/article/pii/S221112471731923X

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