Niemann-Pick type C proteins promote microautophagy by expanding raft-like membrane domains in the yeast vacuole

Niemann-Pick type C proteins promote microautophagy by expanding raft-like membrane domains in the yeast vacuole

Niemann-Pick type C is a storage disease caused by dysfunction of NPC proteins, which transport cholesterol from the lumen of lysosomes to the limiting membrane of that compartment. Using freeze fracture electron microscopy, we show here that the yeast NPC orthologs, Ncr1p and Npc2p, are essential f...

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Bibliographic Details
Main Authors: Takuma Tsuji, Megumi Fujimoto, Tsuyako Tatematsu, Jinglei Cheng, Minami Orii, Sho Takatori, Toyoshi Fujimoto
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-06-01
Series:eLife
Subjects:
microautophagy
Niemann-Pick type C
sterol
raft
vacuole
lipophagy
Online Access:https://elifesciences.org/articles/25960

Internet

https://elifesciences.org/articles/25960

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