Novel Mechanism for Memantine in Attenuating Diabetic Neuropathic Pain in Mice via Downregulating the Spinal HMGB1/TRL4/NF-kB Inflammatory Axis

Novel Mechanism for Memantine in Attenuating Diabetic Neuropathic Pain in Mice via Downregulating the Spinal HMGB1/TRL4/NF-kB Inflammatory Axis

Diabetic neuropathic pain (DNP) is a common diabetic complication that currently lacks an efficient therapy. The aim of the current work was to uncover the anti-allodynic and neuroprotective effects of memantine in a model of mouse diabetic neuropathy and its ameliorative effect on the high-mobility...

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Bibliographic Details
Main Authors: Suliman Y. Alomar, Rehab E. Abo El Gheit, Eman T. Enan, Khaled S. El-Bayoumi, Mohamed Z. Shoaeir, Amany Y. Elkazaz, Sultan S. Al Thagfan, Sawsan A. Zaitone, Rehab M. El-Sayed
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Pharmaceuticals
Subjects:
glutamate
HMGB1/TRL4/NF-kB axis
memantine
mouse diabetic neuropathy
sciatic pathology
Online Access:https://www.mdpi.com/1424-8247/14/4/307

Internet

https://www.mdpi.com/1424-8247/14/4/307

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