Structural modeling, mutation analysis, and in vitro expression of usherin, a major protein in inherited retinal degeneration and hearing loss

Structural modeling, mutation analysis, and in vitro expression of usherin, a major protein in inherited retinal degeneration and hearing loss

Usherin is the most common causative protein associated with autosomal recessive retinitis pigmentosa (RP) and Usher syndrome (USH), which are characterized by retinal degeneration alone and in combination with hearing loss, respectively. Usherin is essential for photoreceptor survival and hair cell...

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Bibliographic Details
Main Authors: Dongmei Yu, Junhuang Zou, Qian Chen, Tian Zhu, Ruifang Sui, Jun Yang
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Protein folding
Recombinant protein expression
Photoreceptor
Hair cell
Structural model
Cell adhesion
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037020302889

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http://www.sciencedirect.com/science/article/pii/S2001037020302889

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