Synthesis of Hantzsch Adducts as Cholinesterases and Calcium Flux inhibitors, Antioxidants and Neuroprotectives

Synthesis of Hantzsch Adducts as Cholinesterases and Calcium Flux inhibitors, Antioxidants and Neuroprotectives

We report herein the design, synthesis, biological evaluation, and molecular modelling of new inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), able to block Ca<sup>+2</sup> channels also showing antioxidant and neuroprotective activities. The new MTDL, dialkyl...

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Bibliographic Details
Main Authors: Irene Pachón Angona, Helene Martin, Solene Daniel, Ignacio Moraleda, Alexandre Bonet, Artur Wnorowski, Maciej Maj, Krzysztof Jozwiak, Isabel Iriepa, Bernard Refouvelet, José Marco-Contelles, Lhassane Ismaili
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
Alzheimer’s disease
Ca<sup>+2</sup> channel antagonists
Hantzsch reaction
multitarget directed ligands
neuroprotection
oxidative stress
Online Access:https://www.mdpi.com/1422-0067/21/20/7652

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https://www.mdpi.com/1422-0067/21/20/7652

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