Genetic evidence for involvement of neuronally expressed S1P₁ receptor in nociceptor sensitization and inflammatory pain.

Genetic evidence for involvement of neuronally expressed S1P₁ receptor in nociceptor sensitization and inflammatory pain.

Sphingosine-1-phosphate (S1P) is a key regulator of immune response. Immune cells, epithelia and blood cells generate high levels of S1P in inflamed tissue. However, it is not known if S1P acts on the endings of nociceptive neurons, thereby contributing to the generation of inflammatory pain. We fou...

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Bibliographic Details
Main Authors: Norbert Mair, Camilla Benetti, Manfred Andratsch, Michael G Leitner, Cristina E Constantin, Maria Camprubí-Robles, Serena Quarta, Wolfgang Biasio, Rohini Kuner, Ian L Gibbins, Michaela Kress, Rainer V Haberberger
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-02-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3040773?pdf=render

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http://europepmc.org/articles/PMC3040773?pdf=render

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