In vitro - in vivo - in silico approach in the development of inhaled drug products: Nanocrystal-based formulations with budesonide as a model drug

In vitro - in vivo - in silico approach in the development of inhaled drug products: Nanocrystal-based formulations with budesonide as a model drug

This study aims to understand the absorption patterns of three different kinds of inhaled formulations via in silico modeling using budesonide (BUD) as a model drug. The formulations investigated in this study are: (i) commercially available micronized BUD mixed with lactose (BUD-PT), (ii) BUD nanoc...

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Bibliographic Details
Main Authors: Changzhi Shi, Jelisaveta Ignjatović, Tingting Liu, Meihua Han, Dongmei Cun, Jelena Đuriš, Mingshi Yang, Sandra Cvijić
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Asian Journal of Pharmaceutical Sciences
Subjects:
Pulmonary drug delivery
Budesonide
Nanocrystal suspension
Nanocrystal-embedded microparticles
In silico physiologically-based pharmacokinetic modeling
Online Access:http://www.sciencedirect.com/science/article/pii/S1818087620314628

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http://www.sciencedirect.com/science/article/pii/S1818087620314628

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