Diagnostic accuracy of a liquid chromatography-tandem mass spectrometry assay in small hair samples for rifampin-resistant tuberculosis drug concentrations in a routine care setting

Diagnostic accuracy of a liquid chromatography-tandem mass spectrometry assay in small hair samples for rifampin-resistant tuberculosis drug concentrations in a routine care setting

Abstract Background Treatment monitoring of drug-resistant tuberculosis (DR-TB) in resource-limited settings is challenging. We developed a multi-analyte assay for eleven anti-TB drugs in small hair samples as an objective metric of drug exposure. Methods Small hair samples were collected from parti...

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Bibliographic Details
Main Authors: John Metcalfe, Peter Bacchetti, Ali Esmail, Andrew Reckers, David Aguilar, Anita Wen, Shu Huo, Winnie R. Muyindike, Judith A. Hahn, Keertan Dheda, Monica Gandhi, Roy Gerona
Format: Article
Language:English
Published: BMC 2021-01-01
Series:BMC Infectious Diseases
Subjects:
LC-MS/MS
Hair
Multidrug-resistant tuberculosis
Online Access:https://doi.org/10.1186/s12879-020-05738-5

Internet

https://doi.org/10.1186/s12879-020-05738-5

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