Novel Patient Metastatic Pleural Effusion-Derived Xenograft Model of Renal Medullary Carcinoma Demonstrates Therapeutic Efficacy of Sunitinib

Novel Patient Metastatic Pleural Effusion-Derived Xenograft Model of Renal Medullary Carcinoma Demonstrates Therapeutic Efficacy of Sunitinib

BackgroundRenal medullary carcinoma (RMC) is a rare but aggressive tumor often complicated by early lung metastasis with few treatment options and very poor outcomes. There are currently no verified RMC patient-derived xenograft (PDX) mouse models established from metastatic pleural effusion (PE) av...

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Bibliographic Details
Main Authors: Alex Q. Lee, Masami Ijiri, Ryan Rodriguez, Regina Gandour-Edwards, Joyce Lee, Clifford G. Tepper, Yueju Li, Laurel Beckett, Kit Lam, Neal Goodwin, Noriko Satake
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Oncology
Subjects:
renal medullary carcinoma
sunitinib
multikinase inhibitor
patient-derived xenograft model
metastatic pleural effusion
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.648097/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.648097/full

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