Functional enhancement of AT1R potency in the presence of the TPαR is revealed by a comprehensive 7TM receptor co-expression screen.

Functional enhancement of AT1R potency in the presence of the TPαR is revealed by a comprehensive 7TM receptor co-expression screen.

BACKGROUND: Functional cross-talk between seven transmembrane (7TM) receptors can dramatically alter their pharmacological properties, both in vitro and in vivo. This represents an opportunity for the development of novel therapeutics that potentially target more specific biological effects while ca...

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Bibliographic Details
Main Authors: Jonas Tind Hansen, Christina Lyngsø, Tobias Speerschneider, Pernille B L Hansen, Céline Galés, David M Weiner, Søren P Sheikh, Ethan S Burstein, Jakob Lerche Hansen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3597553?pdf=render

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http://europepmc.org/articles/PMC3597553?pdf=render

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