Nutrient deprivation and lysosomal stress induce activation of TFEB in retinal pigment epithelial cells

Abstract Background Induction of lysosomal function and autophagy is regarded as an adaptive mechanism in response to cellular stress. The transcription factor EB (TFEB) has been identified as a master regulator of lysosomal function and autophagy. TFEB is a member of the microphthalmia family of bH...

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Bibliographic Details
Main Authors: Hsuan-Yeh Pan, Abdulla H. Alamri, Mallika Valapala
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Cellular & Molecular Biology Letters
Subjects:
Online Access:http://link.springer.com/article/10.1186/s11658-019-0159-8