Nutrient deprivation and lysosomal stress induce activation of TFEB in retinal pigment epithelial cells
Abstract Background Induction of lysosomal function and autophagy is regarded as an adaptive mechanism in response to cellular stress. The transcription factor EB (TFEB) has been identified as a master regulator of lysosomal function and autophagy. TFEB is a member of the microphthalmia family of bH...
Main Authors: | , , |
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Format: | Article |
Language: | English |
Published: |
BMC
2019-05-01
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Series: | Cellular & Molecular Biology Letters |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s11658-019-0159-8 |