Quantitative not qualitative histology differentiates aneurysmal from nondilated ascending aortas and reveals a net gain of medial components

Abstract Medial degeneration is a common histopathological finding in aortopathy and is considered a mechanism for dilatation. We investigated if medial degeneration is specific for sporadic thoracic aortic aneurysms versus nondilated aortas. Specimens were graded by pathologists, blinded to the cli...

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Bibliographic Details
Main Authors: Sameh Yousef, Nana Matsumoto, Issam Dabe, Makoto Mori, Alden B. Landry, Shin-Rong Lee, Yuki Kawamura, Chen Yang, Guangxin Li, Roland Assi, Prashanth Vallabhajosyula, Arnar Geirsson, Gilbert Moeckel, Jay D. Humphrey, George Tellides
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-92659-1