Determination of levodopa in human plasma by high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS): application to a bioequivalence study

Determination of levodopa in human plasma by high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS): application to a bioequivalence study

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A sensitive, accurate and simple method using HPLC-MS/MS was developed and validated for levodopa quantitation in human plasma. Analysis was achieved on a pursuit® C18 analytical column (5 µm; 150 x 4.6 mm i.d.) using a mobile phase (methanol and water , 90:10, v/v) containing formic acid 0.5% v/v,...

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Bibliographic Details
Main Authors: Heliana F. Martins, Douglas P. Pinto, Viviane de A. Nascimento, Marlice A. S. Marques, Fábio C. Amendoeira
Format: Article
Language:English
Published: Sociedade Brasileira de Química 2013-01-01
Series:Química Nova
Subjects:
levodopa
HPLC-ESI-MS/MS
bioequivalence
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422013000100028

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422013000100028

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