Improved solubility, dissolution rate, and oral bioavailability of main biflavonoids from Selaginella doederleinii extract by amorphous solid dispersion

Improved solubility, dissolution rate, and oral bioavailability of main biflavonoids from Selaginella doederleinii extract by amorphous solid dispersion

Amentoflavone, robustaflavone, 2″,3″-dihydro-3′,3‴-biapigenin, 3′,3‴-binaringenin, and delicaflavone are five major hydrophobic components in the total biflavonoids extract from Selaginella doederleinii (TBESD) that display favorable anticancer properties. The purpose of this study was to develop a...

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Bibliographic Details
Main Authors: Bing Chen, Xuewen Wang, Yanyan Zhang, Kangping Huang, Hao Liu, Dafen Xu, Shaoguang Li, Qicai Liu, Jianyong Huang, Hong Yao, Xinhua Lin
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Drug Delivery
Subjects:
selaginella doederleinii
biflavonoids
amorphous solid dispersions
polyvinylpyrrolidone k-30
oral bioavailability
Online Access:http://dx.doi.org/10.1080/10717544.2020.1716876

Internet

http://dx.doi.org/10.1080/10717544.2020.1716876

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