Bone Marrow Mesenchymal Stem Cell-Derived Exosomal miR-25 Regulates the Ubiquitination and Degradation of Runx2 by SMURF1 to Promote Fracture Healing in Mice

Bone Marrow Mesenchymal Stem Cell-Derived Exosomal miR-25 Regulates the Ubiquitination and Degradation of Runx2 by SMURF1 to Promote Fracture Healing in Mice

Recent evidence has demonstrated that mesenchymal stem cells (MSCs) can release a large number of functionally specific microRNA (miRNA) microvesicles that play a role in promoting osteogenic differentiation, but the specific mechanism is not yet clear. Under such context, this study aims to elucida...

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Bibliographic Details
Main Authors: Yikun Jiang, Jun Zhang, Zhengwei Li, Guoliang Jia
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Medicine
Subjects:
fracture healing
BMSC-Exo
miR-25
SMURF1
ubiquitination
Runx2
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2020.577578/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2020.577578/full

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