Proteolytic Cleavages in the VEGF Family: Generating Diversity Among Angiogenic VEGFs, Essential for the Activation of Lymphangiogenic VEGFs

Proteolytic Cleavages in the VEGF Family: Generating Diversity Among Angiogenic VEGFs, Essential for the Activation of Lymphangiogenic VEGFs

Specific proteolytic cleavages turn on, modify, or turn off the activity of vascular endothelial growth factors (VEGFs). Proteolysis is most prominent among the lymph­angiogenic VEGF-C and VEGF-D, which are synthesized as precursors that need to undergo enzymatic removal of their C- and N-terminal p...

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Bibliographic Details
Main Authors: Jaana Künnapuu, Honey Bokharaie, Michael Jeltsch
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Biology
Subjects:
vascular endothelial growth factors (VEGFs)
VEGF-A
PlGF
VEGF-B
VEGF-C
VEGF-D
Online Access:https://www.mdpi.com/2079-7737/10/2/167

Internet

https://www.mdpi.com/2079-7737/10/2/167

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