KRAS(G12C)–AMG 510 interaction dynamics revealed by all-atom molecular dynamics simulations
Abstract The first KRAS(G12C) targeting inhibitor in clinical development, AMG 510, has shown promising antitumor activity in clinical trials. On the molecular level, however, the interaction dynamics of this covalently bound drug–protein complex has been undetermined. Here, we disclose the interact...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2020-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-020-68950-y |