FOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiation

FOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiation

Genetic ablation of Mitochondrial Ca2+ uptake protein 1 (MICU1) in mouse induces higher rates of perinatal lethality. Here the authors show that MICU1 expression is regulated by hypoxia in a FOXD1-dependent manner, establishing a cyclic switch between glycolytic and oxidative metabolism during devel...

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Main Authors: Santhanam Shanmughapriya, Dhanendra Tomar, Zhiwei Dong, Katherine J. Slovik, Neeharika Nemani, Kalimuthusamy Natarajaseenivasan, Edmund Carvalho, Christy Lu, Kaitlyn Corrigan, Venkata Naga Srikanth Garikipati, Jessica Ibetti, Sudarsan Rajan, Carlos Barrero, Kurt Chuprun, Raj Kishore, Salim Merali, Ying Tian, Wenli Yang, Muniswamy Madesh
Format: Article
Language:English
Published: Nature Publishing Group 2018-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05856-4
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spelling doaj-5af6e51c9e9c49309cc33ce6b1c415cc2021-05-11T10:25:24ZengNature Publishing GroupNature Communications2041-17232018-08-019111210.1038/s41467-018-05856-4FOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiationSanthanam Shanmughapriya0Dhanendra Tomar1Zhiwei Dong2Katherine J. Slovik3Neeharika Nemani4Kalimuthusamy Natarajaseenivasan5Edmund Carvalho6Christy Lu7Kaitlyn Corrigan8Venkata Naga Srikanth Garikipati9Jessica Ibetti10Sudarsan Rajan11Carlos Barrero12Kurt Chuprun13Raj Kishore14Salim Merali15Ying Tian16Wenli Yang17Muniswamy Madesh18Department of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple UniversityDepartment of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple UniversityDepartment of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple UniversityInstitute for Regenerative Medicine, University of PennsylvaniaDepartment of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple UniversityDepartment of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple UniversityDepartment of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple UniversityDepartment of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple UniversityDepartment of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple UniversityCenter for Translational Medicine, Lewis Katz School of Medicine at Temple UniversityCenter for Translational Medicine, Lewis Katz School of Medicine at Temple UniversityDepartment of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple UniversityDepartment of Pharmaceutical Sciences, Temple UniversityCenter for Translational Medicine, Lewis Katz School of Medicine at Temple UniversityCenter for Translational Medicine, Lewis Katz School of Medicine at Temple UniversityDepartment of Pharmaceutical Sciences, Temple UniversityCenter for Translational Medicine, Lewis Katz School of Medicine at Temple UniversityInstitute for Regenerative Medicine, University of PennsylvaniaDepartment of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple UniversityGenetic ablation of Mitochondrial Ca2+ uptake protein 1 (MICU1) in mouse induces higher rates of perinatal lethality. Here the authors show that MICU1 expression is regulated by hypoxia in a FOXD1-dependent manner, establishing a cyclic switch between glycolytic and oxidative metabolism during development.https://doi.org/10.1038/s41467-018-05856-4
collection DOAJ
language English
format Article
sources DOAJ
author Santhanam Shanmughapriya
Dhanendra Tomar
Zhiwei Dong
Katherine J. Slovik
Neeharika Nemani
Kalimuthusamy Natarajaseenivasan
Edmund Carvalho
Christy Lu
Kaitlyn Corrigan
Venkata Naga Srikanth Garikipati
Jessica Ibetti
Sudarsan Rajan
Carlos Barrero
Kurt Chuprun
Raj Kishore
Salim Merali
Ying Tian
Wenli Yang
Muniswamy Madesh
spellingShingle Santhanam Shanmughapriya
Dhanendra Tomar
Zhiwei Dong
Katherine J. Slovik
Neeharika Nemani
Kalimuthusamy Natarajaseenivasan
Edmund Carvalho
Christy Lu
Kaitlyn Corrigan
Venkata Naga Srikanth Garikipati
Jessica Ibetti
Sudarsan Rajan
Carlos Barrero
Kurt Chuprun
Raj Kishore
Salim Merali
Ying Tian
Wenli Yang
Muniswamy Madesh
FOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiation
Nature Communications
author_facet Santhanam Shanmughapriya
Dhanendra Tomar
Zhiwei Dong
Katherine J. Slovik
Neeharika Nemani
Kalimuthusamy Natarajaseenivasan
Edmund Carvalho
Christy Lu
Kaitlyn Corrigan
Venkata Naga Srikanth Garikipati
Jessica Ibetti
Sudarsan Rajan
Carlos Barrero
Kurt Chuprun
Raj Kishore
Salim Merali
Ying Tian
Wenli Yang
Muniswamy Madesh
author_sort Santhanam Shanmughapriya
title FOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiation
title_short FOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiation
title_full FOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiation
title_fullStr FOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiation
title_full_unstemmed FOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiation
title_sort foxd1-dependent micu1 expression regulates mitochondrial activity and cell differentiation
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-08-01
description Genetic ablation of Mitochondrial Ca2+ uptake protein 1 (MICU1) in mouse induces higher rates of perinatal lethality. Here the authors show that MICU1 expression is regulated by hypoxia in a FOXD1-dependent manner, establishing a cyclic switch between glycolytic and oxidative metabolism during development.
url https://doi.org/10.1038/s41467-018-05856-4
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