Homoarginine ameliorates diabetic nephropathy independent of nitric oxide synthase‐3

by Michael D. Wetzel, Kristen Stanley, Soumya Maity, Muniswamy Madesh, Jean C. Bopassa, Alaa S. Awad
Published 2021-03-01

Selective inhibition of arginase-2 in endothelial cells but not proximal tubules reduces renal fibrosis

by Michael D. Wetzel, Kristen Stanley, Wei Wei Wang, Soumya Maity, Muniswamy Madesh, W. Brian Reeves, Alaa S. Awad
Published 2020-10-01

The cytoprotective role of DJ-1 and p45 NFE2 against human primary alveolar type II cell injury and emphysema

by Li Hui Tan, Karim Bahmed, Chih-Ru Lin, Nathaniel Marchetti, Sudhir Bolla, Gerard J. Criner, Steven Kelsen, Muniswamy Madesh, Beata Kosmider
Published 2018-02-01

HIV-1 Nef-induced cardiotoxicity through dysregulation of autophagy

by Manish K. Gupta, Rafal Kaminski, Brian Mullen, Jennifer Gordon, Tricia H. Burdo, Joseph Y. Cheung, Arthur M. Feldman, Muniswamy Madesh, Kamel Khalili
Published 2017-08-01

Mitochondrial dysfunction in human primary alveolar type II cells in emphysemaResearch in context

by Beata Kosmider, Chih-Ru Lin, Loukmane Karim, Dhanendra Tomar, Liudmila Vlasenko, Nathaniel Marchetti, Sudhir Bolla, Muniswamy Madesh, Gerard J. Criner, Karim Bahmed
Published 2019-08-01

Mitochondrial Ca2+ and membrane potential, an alternative pathway for Interleukin 6 to regulate CD4 cell effector function

by Rui Yang, Dario Lirussi, Tina M Thornton, Dawn M Jelley-Gibbs, Sean A Diehl, Laure K Case, Muniswamy Madesh, Douglas J Taatjes, Cory Teuscher, Laura Haynes, Mercedes Rincón
Published 2015-05-01

xCT (SLC7A11) expression confers intrinsic resistance to physical plasma treatment in tumor cells

by Sander Bekeschus, Sebastian Eisenmann, Sanjeev Kumar Sagwal, Yana Bodnar, Juliane Moritz, Broder Poschkamp, Ingo Stoffels, Steffen Emmert, Muniswamy Madesh, Klaus-Dieter Weltmann, Thomas von Woedtke, Rajesh Kumar Gandhirajan
Published 2020-02-01

Insulin resistance is mechanistically linked to hepatic mitochondrial remodeling in non-alcoholic fatty liver disease

by Chris E. Shannon, Mukundan Ragavan, Juan Pablo Palavicini, Marcel Fourcaudot, Terry M Bakewell, Ivan A. Valdez, Iriscilla Ayala, Eunsook S. Jin, Muniswamy Madesh, Xianlin Han, Matthew E. Merritt, Luke Norton
Published 2021-03-01

The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition

by Timothy S. Luongo, Jonathan P. Lambert, Ancai Yuan, Xueqian Zhang, Polina Gross, Jianliang Song, Santhanam Shanmughapriya, Erhe Gao, Mohit Jain, Steven R. Houser, Walter J. Koch, Joseph Y. Cheung, Muniswamy Madesh, John W. Elrod
Published 2015-07-01

Yeast homologs of human MCUR1 regulate mitochondrial proline metabolism

by Mohammad Zulkifli, John K. Neff, Shrishiv A. Timbalia, Natalie M. Garza, Yingqi Chen, Jeramie D. Watrous, Marta Murgia, Prachi P. Trivedi, Steven K. Anderson, Dhanendra Tomar, Roland Nilsson, Muniswamy Madesh, Mohit Jain, Vishal M. Gohil
Published 2020-09-01

MICU1 Motifs Define Mitochondrial Calcium Uniporter Binding and Activity

by Nicholas E. Hoffman, Harish C. Chandramoorthy, Santhanam Shamugapriya, Xueqian Zhang, Sudarsan Rajan, Karthik Mallilankaraman, Rajesh Kumar Gandhirajan, Ronald J. Vagnozzi, Lucas M. Ferrer, Krishnalatha Sreekrishnanilayam, Kalimuthusamy Natarajaseenivasan, Sandhya Vallem, Thomas Force, Eric T. Choi, Joseph Y. Cheung, Muniswamy Madesh
Published 2013-12-01

FOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiation

by Santhanam Shanmughapriya, Dhanendra Tomar, Zhiwei Dong, Katherine J. Slovik, Neeharika Nemani, Kalimuthusamy Natarajaseenivasan, Edmund Carvalho, Christy Lu, Kaitlyn Corrigan, Venkata Naga Srikanth Garikipati, Jessica Ibetti, Sudarsan Rajan, Carlos Barrero, Kurt Chuprun, Raj Kishore, Salim Merali, Ying Tian, Wenli Yang, Muniswamy Madesh
Published 2018-08-01

MIRO-1 Determines Mitochondrial Shape Transition upon GPCR Activation and Ca2+ Stress

by Neeharika Nemani, Edmund Carvalho, Dhanendra Tomar, Zhiwei Dong, Andrea Ketschek, Sarah L. Breves, Fabián Jaña, Alison M. Worth, Julie Heffler, Palaniappan Palaniappan, Aparna Tripathi, Ramasamy Subbiah, Massimo F. Riitano, Ajay Seelam, Thomas Manfred, Kie Itoh, Shuxia Meng, Hiromi Sesaki, William J. Craigen, Sudarsan Rajan, Santhanam Shanmughapriya, Jeffrey Caplan, Benjamin L. Prosser, Donald L. Gill, Peter B. Stathopulos, Gianluca Gallo, David C. Chan, Prashant Mishra, Muniswamy Madesh
Published 2018-04-01

Blockade of MCU-Mediated Ca2+ Uptake Perturbs Lipid Metabolism via PP4-Dependent AMPK Dephosphorylation

by Dhanendra Tomar, Fabián Jaña, Zhiwei Dong, William J. Quinn, III, Pooja Jadiya, Sarah L. Breves, Cassidy C. Daw, Subramanya Srikantan, Santhanam Shanmughapriya, Neeharika Nemani, Edmund Carvalho, Aparna Tripathi, Alison M. Worth, Xueqian Zhang, Roshanak Razmpour, Ajay Seelam, Stephen Rhode, Anuj V. Mehta, Michael Murray, Daniel Slade, Servio H. Ramirez, Prashant Mishra, Glenn S. Gerhard, Jeffrey Caplan, Luke Norton, Kumar Sharma, Sudarsan Rajan, Darius Balciunas, Dayanjan S. Wijesinghe, Rexford S. Ahima, Joseph A. Baur, Muniswamy Madesh
Published 2019-03-01

Adeno-Associated Virus Serotype 9–Driven Expression of BAG3 Improves Left Ventricular Function in Murine Hearts With Left Ventricular Dysfunction Secondary to a Myocardial Infarcti...

by Tijana Knezevic, PhD, Valerie D. Myers, MS, Feifei Su, MD, PhD, JuFang Wang, MD, Jianliang Song, MD, PhD, Xue-Qian Zhang, MD, Erhe Gao, MD, PhD, Guofeng Gao, MD, PhD, Muniswamy Madesh, PhD, Manish K. Gupta, PhD, Jennifer Gordon, PhD, Kristen N. Weiner, BS, Joseph Rabinowitz, PhD, Frederick V. Ramsey, PhD, Douglas G. Tilley, PhD, Kamel Khalili, PhD, Joseph Y. Cheung, MD, PhD, Arthur M. Feldman, MD, PhD
Published 2016-12-01

MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioenergetics

by Dhanendra Tomar, Zhiwei Dong, Santhanam Shanmughapriya, Diana A. Koch, Toby Thomas, Nicholas E. Hoffman, Shrishiv A. Timbalia, Samuel J. Goldman, Sarah L. Breves, Daniel P. Corbally, Neeharika Nemani, Joseph P. Fairweather, Allison R. Cutri, Xueqian Zhang, Jianliang Song, Fabián Jaña, Jianhe Huang, Carlos Barrero, Joseph E. Rabinowitz, Timothy S. Luongo, Sarah M. Schumacher, Michael E. Rockman, Alexander Dietrich, Salim Merali, Jeffrey Caplan, Peter Stathopulos, Rexford S. Ahima, Joseph Y. Cheung, Steven R. Houser, Walter J. Koch, Vickas Patel, Vishal M. Gohil, John W. Elrod, Sudarsan Rajan, Muniswamy Madesh
Published 2016-05-01