Silencing Lysine-Specific Histone Demethylase 1 (LSD1) Causes Increased HP1-Positive Chromatin, Stimulation of DNA Repair Processes, and Dysregulation of Proliferation by Chk1 Phosphorylation in Human Endothelial Cells

Silencing Lysine-Specific Histone Demethylase 1 (LSD1) Causes Increased HP1-Positive Chromatin, Stimulation of DNA Repair Processes, and Dysregulation of Proliferation by Chk1 Phosphorylation in Human Endothelial Cells

The methylation of histone lysine residues modifies chromatin conformation and regulates the expression of genes implicated in cell metabolism. Lysine-specific demethylase 1 (LSD1) is a flavin-dependent monoamine oxidase that can demethylate mono- and dimethylated histone lysines 4 and 9 (H3K4 and H...

Full description

Bibliographic Details
Main Authors: Martyna Wojtala, Arkadiusz Dąbek, Dorota Rybaczek, Agnieszka Śliwińska, Ewa Świderska, Katarzyna Słapek, Assam El-Osta, Aneta Balcerczyk
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Cells
Subjects:
lsd1
histone posttranslational modifications
cell cycle
chk1
chromatin remodeling
dna damage and repair
Online Access:https://www.mdpi.com/2073-4409/8/10/1212

Internet

https://www.mdpi.com/2073-4409/8/10/1212

Similar Items