Highly multiplexed genome engineering using CRISPR/Cas9 gRNA arrays.

Highly multiplexed genome engineering using CRISPR/Cas9 gRNA arrays.

The CRISPR/Cas9 system is an RNA guided nuclease system that evolved as a mechanism of adaptive immunity in bacteria. This system has been adopted for numerous genome engineering applications in research and recently, therapeutics. The CRISPR/Cas9 system has been largely implemented by delivery of C...

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Bibliographic Details
Main Authors: Morito Kurata, Natalie K Wolf, Walker S Lahr, Madison T Weg, Mitchell G Kluesner, Samantha Lee, Kai Hui, Masano Shiraiwa, Beau R Webber, Branden S Moriarity
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6141065?pdf=render

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http://europepmc.org/articles/PMC6141065?pdf=render

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