Melatonin improves brain function in a model of chronic Gulf War Illness with modulation of oxidative stress, NLRP3 inflammasomes, and BDNF-ERK-CREB pathway in the hippocampus

Melatonin improves brain function in a model of chronic Gulf War Illness with modulation of oxidative stress, NLRP3 inflammasomes, and BDNF-ERK-CREB pathway in the hippocampus

Persistent cognitive and mood dysfunction is the primary CNS symptom in veterans afflicted with Gulf War Illness (GWI). This study investigated the efficacy of melatonin (MEL) for improving cognitive and mood function with antioxidant, antiinflammatory, and pro-cognitive effects in a rat model of ch...

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Bibliographic Details
Main Authors: Leelavathi N. Madhu, Maheedhar Kodali, Sahithi Attaluri, Bing Shuai, Laila Melissari, Xiaolan Rao, Ashok K. Shetty
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Redox Biology
Subjects:
Brain-derived neurotrophic factor
cAMP response element-binding protein
Cognitive and mood function
Inflammasomes
Mitochondria
Neuroinflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S221323172100121X

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http://www.sciencedirect.com/science/article/pii/S221323172100121X

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