Endothelium-derived Cdk5 deficit aggravates air pollution-induced peripheral vasoconstriction through AT1R upregulation

Endothelium-derived Cdk5 deficit aggravates air pollution-induced peripheral vasoconstriction through AT1R upregulation

PM2.5 infiltrates into circulation and increases the risk of systemic vascular dysfunction. As the first-line barrier against external stimuli, the molecular mechanism of the biological response of vascular endothelial cells to PM2.5 exposure remains unclear. In this study, 4-week-old mice were expo...

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Bibliographic Details
Main Authors: Lu Lu, Lin Yang, Ya-Ping Lu, Qin Jiang, Cui-Rong Wang, Cui-Qing Liu, Nan Xu, Shan Jiang, Gang Zhang, En-Yin Lai, Feng Han, Ying-Mei Lu
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Ecotoxicology and Environmental Safety
Subjects:
PM2.5
Vascular endothelium
Cdk5
Angiotensin II
AT1R
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651321004255

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http://www.sciencedirect.com/science/article/pii/S0147651321004255

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